不同方案药物治疗异位妊娠疗效比较
【关键词】 药物。
摘要：目的：探讨甲氨喋呤(MTX)配合米非司酮不同给药方式治疗异位妊娠的疗效。方法：对136例异位妊娠患者随机分为MTX分次注射配合米非司酮(A组)；MTX单次注射配合米非司酮(B组)；单用米非司酮(C组)进行疗效比较。结果：A、B两组明显缩短血β—hCG降至正常范围的时间，减少住院日，提高治疗成功率(p＜0.05)。结论：MTX分次给药和单次给药配合米非司酮治疗异位妊娠，疗效高，副作用少。尤其是分次MTX肌肉注射配合米非司酮疗效更优，临床上值的推广应用。
Comparison of Pharmacotherapy Which is Given in Different Ways in the Treatment of Ectopic Pregnancy。
Abstract: Objective: To evaluate the effectiveness of treatment in ectopic pregnancy by methotrexate(MTX) and mifepristone ,which is given in different ways.Method:136 cases were divided into group A,B and C.Group A was treated with MTX and mifepristone, MTX is given by many times,group B was treated with MTX and mifepristone ,MTX is given by one time,and group C was treated only with mifepristone. Result: Group A,B show great differences in shortening the time of blood β—hCG restoring to normal level, decreasing days in hospital,and raising cure rate than than of in group C(p＜0.01) . Conclusion: The combination of MTX and mifepristone in traeting ectopic pregnancy is an effective method with highly successful rate and minor side effect.
Key words: Ectopic pregnancy; Methotrexate; Mifepristone 现将我院对136例异位妊娠患者选用不同方案药物治疗的结果分析如下。
1 资料与方法。
1.1 病例选择原则 ①生命体征稳定，无内出血或内出血少，无下腹痛或短暂下腹痛。②B型超声检查：异位妊娠包块≤3cm。③肝、肾功能正常，外周血白细胞＞4×109／L。④要求保守治疗，希望生育。⑤血β—hCG＜15000IU／L。
1.2 一般资料：1998年1月至2004年1月对住院确诊为异位妊娠并符合上述条件的136例患者纳为研究对象，年龄20～36(25.5±9.5)岁，有停经史者108例，停经时间34～56(41.4±14.3)d。初孕妇35例，有孕产史101例。随机分成A、B、C三组，各组间年龄、停经时间、孕产次及临床表现经统计学处理，无差异。A组：46例，MTX分次给药配合米非司酮；B组45例，MTX单次给药配合米非司酮；C组：45例单纯给予米非司酮。
1.3 给药方法 A组：MTX 20mg，肌肉注射，每天一次，连续5ｄ；米非司酮50，每天二次，连用5ｄ；B组：MTX50／ｍ2单次肌肉注射；米非司酮50，每天二次，连用5ｄ；C组：米非司酮75，每天二次，连用5ｄ。