雷公藤多苷联合吗替麦考酚酯治疗老年IgA肾病疗效观察

[摘要] 目的 为了进一步提高老年IgA肾病患者的临床治疗效果，分析和探讨临床同时应用雷公藤多苷和吗替麦考酚酯治疗的安全性和有效性。

方法 通过随机双盲对照的方法选取60例于2014年2月―2015年2月期间来该院老年科就诊的IgA肾病患者作为研究对象并分为对照组和观察组各30例，其中观察组患者在治疗方案上选取吗替麦考酚酯联合雷公藤多苷治疗，而对照组患者在治疗方案上选取单用吗替麦考酚酯治疗，比较不同治疗方案的疗效差异。

结果 经过统计分析发现，观察组患者的治疗总有效率为28例（93.33%），对照组患者为24（80.00%），观察组患者显著优于对照组患者，差异有统计学意义（χ2=3.482，P毕业论文网 　　[关键词] 老年IgA肾病；雷公藤多苷；吗替麦考酚酯；临床观察 　　[中图分类号] R692.3 [文献标识码] A [文章编号] 1674—0742（2016）05（a）—0166—03 　　[Abstract] Objective To analyze and discuss the safety and effectiveness of tripterygium glycosides and mycophenolate mofetil treatment in order to further improve the clinical treatment effect for patients with elderly IgA nephropathy. Methods 60 cases of elderly patients with IgA nephropathy diagnosed in the department of geratology of our hospital from February 2014 to February 2015 were randomly selected as the research objects and divided into two groups with 30 cases in each， the observation group were treated with tripterygium glycosides and mycophenolate mofetil， while the control group were treated with simple mycophenolate mofetil， and the difference in the curative effect of different treatment programs were compared. Results The statistical analysis discovered that the total treatment effective rate in the observation group was obviously better than that in the control group with statistical difference（93.33% vs 80.00%），（28 cases vs 24 cases）， （χ2=3.482， P0.05）。