神经元特异性烯醇化酶、S—100β蛋白与急性脑梗死关系的临床研究
【摘要】 目的 探讨急性脑梗死患者血清神经元特异性烯醇化酶(NSE)和S—100β蛋白的变化及与急性脑梗死的关系。方法 采用酶联免疫吸附法测定80例急性脑梗死患者NSE、S—B100β蛋白及40例健康体检者(对照组)血清NSE和S—100β蛋白含量。 结果 急性脑梗死患者血清NSE和S—100β蛋白浓度均明显高于对照组, 差异有统计学意义(P毕业论文网 【关键词】 急性脑梗死;神经元特异性烯醇化酶; S—100β蛋白;神经功能缺损 Clinical correlative study between the serum s—100β,NSE and acute cerebral infarction WANG Qing—feng.Department of Neurology Chinese Medical Hospital of Kaifeng, Henan 475000,China 作者单位:475000河南省开封市中医院神经内科 ? 【Abstract】 Objective To explore the changes of the serum S—100βand NSE and evaluate the clinical significance of these two indexes in patients with acute cerebral infarction. Methods 80 cases of acute cerebral infarction were selected. The concentration of S —100βand the level of NSE in blood plasm of these patients were detected dynamically with application of ELISA. and compared with 40 healthy examinations(control group). Results The levels of S—100β and NSE in serum of patients with acute cerebral infarction were markedly higher than those in the control group (P5.0 cm2)19例。 1.3 检测方法 患者起病后24 h内采静脉血5 ml,于30 min内离心取上清液,置—70℃冰箱保存待测。正常对照组血标本处理同急性脑梗死组。NSE和S—100β蛋白采用酶联免疫吸附测定法检测,严格按照说明书进行。试剂盒均由中国同位素公司北方免疫试剂研究所提供。 1.4 统计学方法 应用SPSS11.0软件进行数据处理。计量资料以均数±标准差(x±s) 表示,组间比较采用t检验。P。
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注:与轻型比较,△P。